IMP-1710

SKU: orb1692756

Description

IMP-1710 is a potent and selective UCH-L1 inhibitor, demonstrating an IC50 of 38 nM. It exhibits antifibrotic activity and is a valuable research tool for studying fibrosis in both cellular and animal models.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 2383117-96-0
• MW: 381.43
• Purity: 99.30% (May vary between batches)
• Formula: C₂₃H₁₉N₅O
• SMILES: C(=O)(N1C=2C(=C(C=CC2)C=3C=4C(NC3)=NC=C(C#C)C4)CC1)[C@H]5N(C#N)CCC5
• Target: DUB
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:4.5 mg/mL (11.8 mM);DMSO:20 mg/mL (52.43 mM);Chloroform:9 mg/mL (23.6 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.24 mM)

Bioactivity

• Target IC50:
  UCHL1:38 nM (fluorescence polarization assay)
• In Vitro:
  METHODS: Unbiased quantitative chemical proteome analysis (Figure 22a) was used in HEK293 cells treated with IMP-1710 (2, 20 or 200 nM) or vehicle (DMSO) for 10, 60 or 180 minutes to determine the overall proteome. Selectivity. RESULTS IMP-1710 significantly enriched ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) and fibroblast growth factor receptor 2 (FGFR2) at 20 nM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IMP1710, IMP-1710, IMP 1710, UCH-L1

Compound Identifiers

PubChem CID

156588934