IMP-1088

SKU: orb1298162

Description

IMP-1088

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2059148-82-0
• MW: 453.53
• Purity: 98.26% (May vary between batches)
• Formula: C₂₅H₂₉F₂N₅O
• SMILES: CN(C)Cc1nn(C)c2ccc(cc12)-c1ccc(F)c(F)c1OCCc1c(C)nn(C)c1C
• Target: DNA/RNA Synthesis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.28 mM);DMSO:95 mg/mL (209.47 mM)

Bioactivity

• Target IC50:
  NMT2 (human):<1 nM|NMT1 (human):<1 nM
• In Vitro:
  IMP-1088 (1-1000 nM) inhibits production of infectious virus and single-cycle replication in primary human bronchial epithelial cells (hBEC) infected with rhinovirus RV-A1 (MOI 5) for 7 hours, and remains effective even when administered up to 3 hours post-infection. Additionally, IMP-1088 (500 nM) blocks virus assembly and inhibits production of infectious rhinovirus particles in HeLa cells infected with rhinovirus RV-A16 (MOI 20) for 6 hours.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IMP 1088, IMP1088, IMP-1088, inhibit, Inhibitor, N-myristoyltransferase-1 (NMT-1), N-myristoyltransferases, NMT1, NMT2, HeLa, hBEC, HsNMT1, HsNMT2, human, epithelial, bronchial, DNASynthesis, DNA Synthesis, DNA/RNA Synthesis, protein, replication, rhinovirus, RNA Synthesis, RNASynthesis, RV-A16, VP0, virus-encoded

Compound Identifiers

PubChem CID

132274735