iHAC

SKU: orb2945373

Description

iHAC is a covalent BRD4-HSP90 targeting chimera based on the (+)-JQ-1 ligand. It demonstrates anti-proliferative activity in cancer cells and has shown efficacy in vivo, suppressing recurrence and metastasis in a 4T1 breast cancer mouse model while eliciting an anti-tumor immune response.

Research Area

Epigenetics & Chromatin

Key Properties

• MW: 1241.56
• Formula: C₅₀H₄₆ClIN₁₆O₇S₃
• SMILES: CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)NCC4=CN(N=N4)CCCC(=O)N(CC#N)S(=O)(=O)C5=CC=C(C=C5)C(=O)NCCCN6C7=NC=NC(=C7N=C6SC8=C(C=C9C(=C8)OCO9)I)N)C1=CC=C(C=C1)Cl)C
• Target: Epigenetic Reader Domain

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676991