Ifosfamide

SKU: orb1225156

Description

A nitrogen mustard alkylating agent used in the treatment of cancer.Chemotherapeutic Agents Approved(In Vitro):Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors. Ifosfamide is activated by the cytochrome P450 family. Ifosfamide (0-5 mM) suppresses the viability of CYP2B1-expressing C8III-1 cells, while it is cytotoxic to the non-CYP2B1-expressing CrFK cells only at high concentration (5 mM). CYP BM3 mutants activates Ifosfamide, and Ifosfamide shows inhibitory activity against human U2OS cells.(In Vivo):Ifosfamide (50 mg/kg, i.p.) treatment before mating increases percentage of post-implantation loss and resorbs fetuses in pregnant rats. Ifosfamide also (50 mg/kg, i.p.) decreases the progesterone in the serum of pregnant rats. However, Ifosfamide causes no obvious difference with the control rats at 25 mg/kg. Ifosfamide (25, 50 mg/kg, i.p.) induces apoptosis and histological changes in the placentas and prenatal rats, most sensitive fetal organs are the brain, liver and kidney.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3778-73-2
• MW: 261.086
• Purity: >98% (HPLC)
• Formula: C₇H₁₅Cl₂N₂O₂P
• SMILES: ClCCNP1(OCCCN1CCCl)=O
• Target: DNA Alkylator
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Ifosfamide (50 mg/kg, i.p.) treatment before mating increases percentage of post-implantation loss and resorbs fetuses in pregnant rats. Ifosfamide also (50 mg/kg, i.p.) decreases the progesterone in the serum of pregnant rats. However, Ifosfamide causes no obvious difference with the control rats at 25 mg/kg. Ifosfamide (25, 50 mg/kg, i.p.) induces apoptosis and histological changes in the placentas and prenatal rats, most sensitive fetal organs are the brain, liver and kidney.
• In Vitro:
  Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors. Ifosfamide is activated by the cytochrome P450 family. Ifosfamide (0-5 mM) suppresses the viability of CYP2B1-expressing C8III-1 cells, while it is cytotoxic to the non-CYP2B1-expressing CrFK cells only at high concentration (5 mM). CYP BM3 mutants activates Ifosfamide, and Ifosfamide shows inhibitory activity against human U2OS cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Isophosphamide | NSC 109724

Quick Database Links

Gene Symbol

DNA Alkylator