Idazoxan hydrochloride

SKU: orb1223977

Description

A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.(In Vivo):Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25 mg/kg. Idazoxan (0.3 and 2.5 mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol.

Key Properties

• CAS Number: 79944-56-2
• MW: 240.69
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₂N₂O₂·HCl
• SMILES: Cl.C1CN=C(N1)C1COC2=CC=CC=C2O1
• Target: Adrenergic Receptor
• Solubility: Water: 100 mM

Bioactivity

• In Vivo:
  Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25 mg/kg. Idazoxan (0.3 and 2.5 mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol. Animal model: Male CD-COBS rats injected with 1 mg/kg haloperidol. Dosage: 0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0 mg/kg. Administration: Subcutaneous injection; for 1 hour. Result: Potently reversed haloperidol-induced catalepsy with an ED50 of 0.25 mg/kg.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Adrenergic Receptor