Idarubicin hydrochloride

SKU: orb1224603

Description

An anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells; inhibits the proliferation of MCF-7 cells with IC50 of 0.1 uM; also induces histone eviction from chromatin.Chemotherapeutic Agents Approved(In Vitro):The IC50 of idarubicin is 3.3±0.4 ng/mL on MCF-7 monolayers and 7.9±1.1 ng/mL in multicellular spheroids. Idarubicin has shown a greater cytotoxicity than daunorubicin or doxorubicin in various in vitro systems. This has been attributed to a better ability of idarubicin to induce the formation of topoisomerase II -mediated DNA breaks.Idarubicin is about 57.5-fold and 25-fold more active than doxorubicin and epirubicin, respectively. Idarubicin produces a concentration-dependent reduction in cell growth, with an IC50 value of approximately 0.01 μM. Idarubicin produced a concentration-dependent inhibition of DNA synthesis.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 57852-57-0
• MW: 533.9548
• Purity: >98% (HPLC)
• Formula: C₂₆H₂₈ClNO₉
• SMILES: O=C1C2=C(O)C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@](O)(C(C)=O)C4)=C4C(O)=C2C(C5=C1C=CC=C5)=O.[H]Cl
• Target: Topoisomerase
• Solubility: 10 mM in DMSO

Bioactivity

• In Vitro:
  The IC50 of Idarubicin hydrochloride is 3.3±0.4 ng/mL on MCF-7 monolayers and 7.9±1.1 ng/mL in multicellular spheroids. Idarubicin hydrochloride has shown a greater cytotoxicity than daunorubicin or doxorubicin in various in vitro systems. This has been attributed to a better ability of idarubicin to induce the formation of topoisomerase II -mediated DNA breaks. Idarubicin hydrochloride is about 57.5-fold and 25-fold more active than doxorubicin and epirubicin, respectively. Idarubicin hydrochloride produces a concentration-dependent reduction in cell growth, with an IC50 value of approximately 0.01 μM. Idarubicin hydrochloride produced a concentration-dependent inhibition of DNA synthesis.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4-Demethoxydaunorubicin hydrochloride

Quick Database Links

Gene Symbol

Topoisomerase