icFSP1

SKU: orb1819107

Description

icFSP1 is a mitochondria-associated regulator of apoptosis-inducing factor (AIF) with demonstrated antitumor properties. This small molecule is utilized in cancer research to study apoptotic pathways and has shown activity in both in vitro cellular assays and in vivo tumor models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 1115910-36-5
• MW: 459.49
• Purity: 99.93%
• Formula: C₂₆H₂₅N₃O₅
• SMILES: O=C1N(C(C)=NC=2C1=CC=CC2)C3=CC=C(NC(CC4=CC(OC)=C(OC)C(OC)=C4)=O)C=C3
• Target: Glutathione Peroxidase,Ferroptosis,Apoptosis
• Solubility: DMSO:55 mg/mL (119.7 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.35 mM)

Bioactivity

• In Vivo:
  In a tumour-bearing mouse model, icFSP1(i.p.) significantly inhibited tumour growth and decreased tumour weight, without affecting body weight. icFSP1 markedly increased the abundance of hFSP1 condensates and immunoreactivity to 4-hydroxynonenal, a lipid peroxidation breakdown product.
• In Vitro:
  icFSP1(5 µM) triggers subcellular relocalization of FSP1 from the membrane and FSP1 condensation before ferroptosis induction, in synergism with GPX4 inhibition.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

icFSP1, apoptosis

Compound Identifiers

PubChem CID

46392030