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Ibezapolstat

SKU: orb1710492

Description

Ibezapolstat

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Images & Validation

Key Properties

CAS Number1275582-97-2
MW423.3
Purity98.00% (May vary between batches)
FormulaC18H20Cl2N6O2
SMILESClc1ccc(CNc2nc3ncn(CCN4CCOCC4)c3c(=O)[nH]2)cc1Cl
TargetOthers

Bioactivity

Target IC50
DNA polymerase IIIC (C. difficile):0.325 μM (Ki)
In Vitro
Ibezapolstat (IBZ) is a competitive inhibitor of the bacterial Pol IIIC enzyme with strong in vitro activity against wild-type, susceptible strains and a MIC50/90 of 4/8μg/mL against C. difficile strains. Ibezapolstat is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C. difficile.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ACX362E, ACX-362E, Ibezapolstat, GLS362E, GLS-362E

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information