I-152

SKU: orb1982296

Description

I-152 is a conjugate of N-acetylcysteine and β-mercaptoethylamine with antiproliferative, antiviral, and immunomodulatory properties. Its utility in viral infection research stems from its ability to activate the NRF2 and ATF4 signaling pathways, as demonstrated in cellular and animal model studies.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 311343-11-0
• MW: 264.37
• Purity: 98.36%
• Formula: C₉H₁₆N₂O₃S₂
• SMILES: [C@H](C(NCCSC(C)=O)=O)(NC(C)=O)CS
• Target: Nrf2
• Solubility: DMSO:80 mg/mL (302.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (12.48 mM)

Bioactivity

• In Vitro:
  When I-152 is treated with RAW 264.7 cells at a concentration of 1 mM, it decreases the level of NRF2 mRNA after 1 h or 2 h; treatment for 0-60 min not only decreases the levels of NRF2 and p53, but also increases the expression of ATF4. In addition, at concentrations of 0.062, 0.125, 0.25, or 1 mM, I-152 was able to increase the levels of Gclc mRNA and Chac1 mRNA after 6 h or 24 h, and increase Chop mRNA expression after 6 h. The expression of Chac1 mRNA was also increased at concentrations of 0.062, 0.125, 0.25, or 1 mM. I-152 also increased GSH levels in RAW 264.7 cells when treated at concentrations of 0.062, 0.125, 0.25, or 1 mM for 2 hours. At a concentration of 1 mM, I-152 treatment for 1 h, 2 h, 6 h and 24 h activated the expression of ATF4 mRNA in RAW 264.7 cells; whereas treatment for 24 h and 48 h produced cytotoxicity and inhibited the growth of RAW 264.7 cells.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Keap1-Nrf2, I152

Compound Identifiers

PubChem CID

484333