Hydroxyurea

SKU: orb1226631

Description

Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.(In Vitro):Hydroxyurea is used in a number of myeloproliferative, neoplastic, HIV, and non-hematological diseases. Treatment of cells in primary culture with 30 μM hydroxyurea for 96 hours significantly increases the fractional HbF content. The Gγ: Aγ-globin mRNA is induced 0.30- to 8-fold in vitro. Hydroxyurea has been shown to block HIV-1 reverse transcription and/or replication in quiescent peripheral blood mononuclear cells and macrophages.(In Vivo):Hydroxyurea therapy producs consistent reductions in WBC and ANC without improvement in anemia over 17 weeks. Hydroxyurea at 50mg/kg produces a reduced white blood cell count, absolute neutrophil count and no improvement in anemia compared to vehicle treated sickle cell mice.

Key Properties

• CAS Number: 127-07-1
• MW: 76.06
• Purity: >98% (HPLC)
• Formula: CH₄N₂O₂
• SMILES: O=C(N)NO
• Target: DNA/RNA Synthesis
• Solubility: Water: 15 mg/mL (197.23 mM); DMSO: 15 mg/mL (197.23 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NCI C04831 | NSC 32065

Quick Database Links

Gene Symbol

DNA/RNA Synthesis