Hydroxy-PEG10-acid

SKU: orb1307409

Description

HO-PEG10-CH2CH2COOH is a polyethylene glycol (PEG) spacer used in constructing PROTAC bifunctional molecules. This hydrophilic linker is employed in both in vitro and in vivo research to enhance solubility and pharmacokinetic properties of targeted protein degraders.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2375611-66-6
• MW: 530.6
• Purity: ≥98%
• Formula: C₂₃H₄₆O₁₃
• SMILES: C(OCCOCCOCCOCCOCCOCCOCCO)COCCOCCOCCC(O)=O
• Target: ADC Linker,PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs, consisting of two ligands connected by a linker—one targeting an E3 ubiquitin ligase and the other the target protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antibody-drug conjugates linkers, ADC Linker, ADCLinker, ADC Linkers, HO-PEG10-CH2CH2COOH, HydroxyPEG10acid, Hydroxy-PEG-10-acid, Hydroxy-PEG10-acid, Hydroxy PEG10 acid, Inhibitor, inhibit, PROTACLinker, PROTAC Linkers, PROTAC Linker, PEGs

Compound Identifiers

PubChem CID

118988535