Hydroxy Itraconazole

SKU: orb1679019

Description

Hydroxy Itraconazole (R63373) is a triazole antifungal agent investigated for its potential role in oncology research. Studies explore its effects on tumor biology in both cellular (in vitro) and animal (in vivo) models, focusing on mechanisms such as Hedgehog signaling pathway inhibition.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 112559-91-8
• MW: 721.63
• Purity: 99.59%
• Formula: C₃₅H₃₈Cl₂N₈O₅
• SMILES: O=C1N(N=CN1C2=CC=C(C=C2)N3CCN(C4=CC=C(OCC5OC(OC5)(C6=CC=C(Cl)C=C6Cl)CN7N=CN=C7)C=C4)CC3)C(C)C(O)C
• Target: Antifungal,Drug Metabolite,Antibacterial
• Solubility: DMSO:80 mg/mL (110.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.57 mM)

Bioactivity

• In Vivo:
  Plasma concentrations of Hydroxy Itraconazole do not correlate well with ITZ doses, probably because the process of forming Hydroxy Itraconazole is saturated. Factors such as serum albumin and GFR affect the pharmacokinetics of ITZ and Hydroxy Itraconazole. When considering antifungal activity, it is important to look not only at plasma concentrations of ITZ, but also at plasma concentrations of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole in immunocompromised patients receiving oral ITZ solutions are similar to those of ITZ. Therefore, since plasma concentrations of ITZ and Hydroxy Itraconazole are highly correlated, determining plasma concentrations of both should be sufficient from a clinical standpoint.
• In Vitro:
  Hydroxy Itraconazole is considered to have antifungal effects in vitro. It contains a triazole ring in its structure and is capable of inhibiting the CYP3A enzyme.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antifungal, Hydroxy Itraconazole, Hydroxyitraconazole, R 63373, R63373, R-63373

Compound Identifiers

PubChem CID

108222