Human Tau-352 / 0N3R Protein, Tag Free, low Endotoxin (MALS verified)

SKU: orb3158094

Description

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.

Research Area

Neuroscience; Immunology & Inflammation

Images & Validation

• Application Notes:
  This protein carries no "tag". The protein has a calculated MW of 36.8 kDa. The protein migrates as 38 kDa, 40 kDa and 45-50 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

• Expression System: E. coli
• Target: Tau
• Reactivity: Human
• Tag: Native
• Expression Region: Met 1 - Leu 352
• Endotoxins: 0.01 EU per μg
• Conjugation: Unconjugated
• MW: 36.8 kDa
• Purity: 95%

Storage & Handling

• Storage: -70°C
• Form/Appearance: Liquid
• Buffer/Preservatives: 20 mM Tris, 150 mM NaCl, pH 7.5
• Expiration Date: 6 months from date of receipt.
• Dry Ice Shipping: Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Tau

RefSeq:P10636