Human GFR alpha-like Protein

• Catalog Number: orb545746
• Category: Proteins
• Description: GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 39.7 kDa
• Target: GFR alpha-like
• Protein Sequence: NP_997293.2
• Source: Human GFR alpha-like, His Tag (orb545746) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Glu 351 (Accession # Q6UXV0-1).
• Expression System: HEK293
• Expression Region: Ser 19 - Glu 351
• Endotoxins: 1.0 EU per μg
• NCBI: NP_997293.2
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: GFR alpha like,GFR alpha-like,GFRAL,GRAL
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.7 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.