Human ASGR1 Protein, Fc Tag

SKU: orb750365

Description

ASGPR, a transmembrane C-type lectin, recognizes a wide variety of ligands that contain either terminal galactose (Gal) or N-acetylgalactosamine (Galc) residues and has been identified as a highly selective receptor on hepatocytes. The ASGR is composed of both a major (ASGR1) and minor subunit (ASGR2). ASGR1 has been shown to be efficiently targeted to the plasma membrane and to undergo constitutive endocytosis and recycling and found mainly expressed in the human liver.

Images & Validation

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Application Notes	This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 52.8 kDa. The protein migrates as 65-75 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

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Expression System	HEK293
Target	ASGR1
Reactivity	Human
Tag	N-Fc
Molecular Weight	52.8 kDa
Expression Region	Gln 62 - Leu 291
Purity	90%
Endotoxins	0.01 EU per μg
Conjugation	Unconjugated

Storage & Handling

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Storage	-20°C
Form/Appearance	Powder
Buffer/Preservatives	PBS, pH 7.4
Expiration Date	6 months from date of receipt.
Disclaimer	For research use only

Human ASGR1(124-291) Protein, hFc Tag [orb2668313]

Conjugation:	Unconjugated
Purity:	The purity of the protein is greater than 90% as determined by SDS-PAGE and Coomassie blue staining.
MW:	The protein has a predicted molecular mass of 45.6 kDa after removal of the signal peptide.

Sizes Available: 100 μg, 10 μg, 50 μg

Human ASGR1(61-160) Protein, hFc Tag [orb2668314]

Conjugation:	Unconjugated
Purity:	The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
MW:	The protein has a predicted molecular mass of 37.2 kDa after removal of the signal peptide. The apparent molecular mass of hFc-ASGR1(61-160) is approximately 35-55 kDa due to glycosylation.

Sizes Available: 100 μg, 10 μg, 50 μg

Mouse ASGR1 Protein, Fc Tag [orb2279543]
Conjugation:
Unconjugated
Purity:
90%
MW:
52.2 kDa
Sizes Available: 100 μg, 1 mg
Cynomolgus ASGR1 Protein, Fc Tag [orb1909746]
Conjugation:
Unconjugated
Purity:
90%
MW:
52.9 kDa
Sizes Available: 1 mg, 100 μg

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Quick Database Links

Gene Symbol

ASGR1

UniProt

P07306

RefSeq:P07306

UniProt Details

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No UniProt data available

NCBI Reference Sequences

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Associated Accession Numbers

Curated reference sequences for the gene transcript and protein product

RefSeq	P07306

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