Human Activin RIB & Activin RIIB Protein, Fc Tag&Fc Tag

• Catalog Number: orb1818950
• Category: Proteins
• Description: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
• Reactivity: Human
• Tag: C-Fc | C-Fc
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 37 kDa & 39.1 kDa
• Target: Activin RIB & Activin RIIB
• Source: Human Activin RIB & Activin RIIB Protein, Fc Tag&Fc Tag (orb1818950) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Glu 126 & Gly 20 - Pro 133 (Accession # P36896-1 & Q13705-1).
• Expression System: HEK293
• Expression Region: Gly 25 - Glu 126 & Gly 20 - Pro 133
• Endotoxins: 1.0 EU per μg
• Storage: -20°C
• Buffer/Preservatives: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
• Note: For research use only
• Application notes: This protein . The protein has a calculated MW of 37 kDa & 39.1 kDa. The protein migrates as 80-95 kDa and > 150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.