HS-276

SKU: orb1687830

Description

HS-276 is a potent and selective TAK1 inhibitor with an IC50 of 8.25 nM, also showing activity against CLK2, GCK, ULK2, and MAP4K5. This orally bioavailable compound is a valuable research tool for investigating rheumatoid arthritis mechanisms in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2767422-72-8
• MW: 419.52
• Purity: 97.67% (May vary between batches)
• Formula: C₂₄H₂₉N₅O₂
• SMILES: C(CC)N1C=2C(N=C1NC(=O)C3=CC(C(N)=O)=CC=C3)=CC=C(CN4CCCCC4)C2
• Target: IRAK,Casein Kinase,MAPK,TNF
• Solubility: DMSO:45 mg/mL (107.27 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.77 mM)

Bioactivity

• Target IC50:
  CSNK1G2:810 nM|CaMKK β1:1280 nM|IRAK4:2500 nM|IRAK1:264 nM|MLK1:5585 nM|CLK2:29 nM|ULK2:63 nM|TAK1:8.25 nM|TAK1:2.5 nM (Ki)|NUAK:270 nM|MAP4K5:125 nM|GCK:33 nM
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TAK1

Compound Identifiers

PubChem CID

164517032