HS-1371

SKU: orb1300441

Description

HS-1371 is a potent and selective small molecule inhibitor of RIP3 kinase, demonstrating an IC50 of 20.8 nM. It is a valuable research tool for investigating necroptosis in vitro and has been utilized in preclinical in vivo models to study inflammatory and ischemic diseases.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2158197-70-5
• MW: 384.47
• Purity: 98.00% (May vary between batches)
• Formula: C₂₄H₂₄N₄O
• SMILES: Cc1ccc(Oc2ccnc3cc(ccc23)-c2cnn(c2)C2CCNCC2)cc1
• Target: RIP kinase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.6 mM);DMSO:16.67 mg/mL (43.36 mM)

Bioactivity

• Target IC50:
  RIP3:20.8 nM
• In Vitro:
  HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, inhibiting TNF-induced necroptosis without affecting TNF-induced apoptosis. This indicates a specific inhibitory effect on RIP3-mediated necroptosis through the suppression of RIP3 kinase activity. HS-1371 may serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HS1371, HS-1371, HS 1371, inhibit, Inhibitor, Receptor-interacting protein kinases, RIPkinase, RIP3, RIPK, RIP kinase

Compound Identifiers

PubChem CID

134817449