HPOB

SKU: orb1703241

Description

HPOB

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1429651-50-2
• MW: 314.34
• Purity: 99.91%
• Formula: C₁₇H₁₈N₂O₄
• SMILES: OCCN(C(=O)Cc1ccc(cc1)C(=O)NO)c1ccccc1
• Target: Apoptosis,HDAC
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.36 mM);DMSO:58 mg/mL (184.51 mM);Ethanol:36 mg/mL (114.53 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  HDAC6:56 nM|HDAC8:2.8 μM|HDAC3/NCOR2:1.7 μM|HDAC10:3.0 μM|HDAC2:4.4 μM|HDAC1:2.9 μM
• In Vivo:
  In HFS cells, HPOB enhances transformation cell death induced by Etoposide, Doxorubicin, or SAHA. HPOB also augments Etoposide-induced transformation cell death in transformed cells via the apoptosis pathway. In both normal (HFS) and transformed (LNCaP, A549, and U87) cells, HPOB induces α-tubulin proteins without affecting histones, inhibiting cell growth without impacting cell viability.
• In Vitro:
  In mice bearing CWR22 human prostate cancer xenografts, the combination of HPOB (300 mg/kg/day) with SAHA significantly inhibits the growth of pre-existing tumors, whereas the use of either compound alone does not exhibit a noticeable inhibitory effect.
• Cell Research:
  Normal (HFS) and transformed (LNCaP, A549, and U87) cells are cultured with indicated doses of HPOB for 72 h. Five micromolars SAHA is a positive control.Graphs were constructed using Prism 5. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, HDAC, HDAC3, HDAC10, HDAC1, HDAC6, HDAC8, Histone deacetylases, HPOB, inhibit, LNCaP, A549, Apoptosis, anticancer, CWR22, cells, selective, tumor, U87

Compound Identifiers

PubChem CID

71532921