Histamine Phosphate

SKU: orb1300683

Description

Histamine phosphate is a potent vasodilator and neurotransmitter that activates histamine receptors and nitric oxide synthase. It is widely used in research to model gastric ulcers and study vascular and inflammatory responses in both in vivo and in vitro experimental systems.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 51-74-1
• MW: 307.14
• Purity: >99.99%
• Formula: C₅H₉N·2H₃O₄P
• SMILES: O.OP(O)(O)=O.OP(O)(O)=O.NCCc1c[nH]cn1
• Target: Histamine Receptor
• Solubility: H2O:10 mM;DMSO:Insoluble

Bioactivity

• In Vivo:
  Histamine phosphate (0.025 mg/kg) produces a mean increase in basilar blood flow of 145% of control in dogs. Histamine phosphate produces considerable increases in basilar blood flow as well as a decrease in femoral arterial blood pressure in dogs when injected intravenously and measured with an electromagnetic flow transducer. Histamine phosphate (4 μg/kg) causes lymph flow to increase from 6.0 to 27.0 (SEM) ml/h in unanesthetized sheep. Histamine phosphate (4 μg/kg) also causes increases in lung water, pulmonary vascular resistance, arterial PCO2, pH, and hematocrit, and decreases in cardiac output and arterial PO2 in unanesthetized sheep. Histamine phosphate (8.3 mg/kg/min) causes no significant change in pulmonary lymph flow (QL) or protein concentration (CL) in anesthetized open-chested dogs, however, both are increased after alloxan. Histamine phosphate (8.3 mg/kg/min) also causes no significant change in the pulmonary capillary membrane filtration coefficient (Kf) and the maximum capillary pressure (PCcritical) in anesthetized open-chested dogs. Histamine phosphate (50 mg/kg) produces a pronounced rise in acid secretion but the output of pepsin remained unchanged in the unanaesthetized intact rat. Histamine phosphate (50 mg/kg) produces maximal stimulation of gastric acid secretion and is free from toxic effects in the unanaesthetized intact rat.
• In Vitro:
  Histamine (10 μM) gives a larger inositol monophosphate accumulation in bovine adrenal chromaffin cells. Histamine (10 μM) stimulates the level of radioactivity into the InsP3-containing fraction in bovine adrenal chromaffin cells. Histamine (100 μM) stimulates incorporation into the InsP3-containing eluate in a less extent than for angiotensin I1 and bradykinin.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

H2 receptor, H1 receptor, Inhibitor, Histamine Phosphate, Histamine, Histamine acid Phosphate, Histamine acid phosphate, Histamine diphosphate, Histamine Diphosphate, HistamineReceptor, Histamine Receptor, inhibit

Compound Identifiers

PubChem CID

16216956