Hispidol

SKU: orb1302955

Description

Hispidol

Research Area

Cell Biology

Key Properties

• CAS Number: 5786-54-9
• MW: 254.24
• Purity: 100.00%
• Formula: C₁₅H₁₀O₄
• SMILES: Oc1ccc(\C=C2/Oc3cc(O)ccc3C2=O)cc1
• Target: TNF
• Solubility: DMSO:6.25 mg/mL (24.58 mM)

Bioactivity

• Target IC50:
  TNF-α:0 50 μM
• In Vivo:
  Oral administration of hispidol suppresses TNBS-induced colitis in a dose-dependent manner. Body weight loss and colon tissue edematous inflammation are recovered significantly the oral administration of hispidol suppresses significantly and dose-dependently TNBS-induced rat colitis. A higher dose (30 mg/kg) of hispidol shows a similar recovery effect to that of 300 mg/kg sulfasalazine. in the colon tissues, TNBS induces a dramatic increase in the level of MPO, a biochemical marker of inflammation, which is suppressed significantly by hispidol in a dose-dependent manner.
• In Vitro:
  Hispidol demonstrates potent inhibitory effects on TNF-α-induced adhesion of monocytes to colonic epithelial cells and LPS-induced TNF-α expression, making it a promising andidate for inflammatory bowel disease (IBD) drug development. This compound not only inhibits TNF-α expression effectively (>70%)—a critical event in IBD progression—but also suppresses AP-1 transcriptional activity, which is essential for high levels of TNF-α expression.
• Animal Research:
  Hispidol is prepapred in corn oil.Rat: To stud the effect o the drugs, hispidol (10 or 30 mg/kg/day in corn oil) is administered orally once in a day, until 5 days after TNBS administration the doses of 10 or 30 mg/kg are selected based on previous studies the concentration o the compound inhibiting 70% and 90% μM) cell-to-cell adhesion is selected and regarded a the in vivo test dose mg/kg). Sulfasalazine (300 mg/kg/day) is administered in corn oil as a positive control. O the 6 h day the rats are sacrificed an the severity of colitis and macroscopic ulceration are evaluated by two independent investigators who are blinded to the experiments the colon tissues (5-7 cm proximal to rectum) are cut and used to measure the amount of myeloperoxidase and fo the histological examination.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Hispidol, (Z)-Hispidol, TNF Receptor, TNF-α

Compound Identifiers

PubChem CID

5281254