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HG-14-10-04

SKU: orb1223336

Description

HG-14-10-04 is a novel potent and specific ALK inhibitor.

Images & Validation

Key Properties

CAS Number1356962-34-9
MW532.08
Purity>98% (HPLC)
FormulaC29H34ClN7O
SMILESCN1CCN(C2CCN(c3ccc(Nc4ncc(Cl)c(c5c[nH]c6c5cccc6)n4)c(OC)c3)CC2)CC1
TargetLPA Receptor
SolubilityDMSO : 13.3 mg/mL. 25.00 mM;

Bioactivity

In Vitro
HG-14-10-04 (example 10) has inhibitory activity against ALK kinase with an IC50 of 20 nM. HG-14-10-04 (compound 17b) exhibits kinase inhibitory activity against EGFRLR/TM, EGFR19del/TM/CS and EGFRLR/TM/CS with IC50s of 15.6 nM, 22.6 nM and 124.5 nM, respectively.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

HG-14-10-04

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  • HG-14-10-04 [orb1303304]

    99.75%

    1356962-34-9

    532.08

    C29H34ClN7O

    5 mg, 10 mg, 100 mg, 1 ml x 10 mM (in DMSO), 1 mg, 200 mg, 50 mg, 25 mg
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Protocol Information

HG-14-10-04 (orb1223336)

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Available Sizes

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200 mg
500 mg
2 mg
$ 130.00
5 mg
$ 180.00
10 mg
$ 270.00
25 mg
$ 370.00
50 mg
$ 460.00
100 mg
$ 650.00