Hematoporphyrin monomethyl ether

SKU: orb1691661

Description

Hematoporphyrin monomethyl ether (HMME) is a porphyrin-based photosensitizer used in photodynamic therapy research. It is applied in studies investigating port wine stain treatment, utilizing its light-activated properties for both in vitro cellular research and in vivo experimental models.

Research Area

Cell Biology

Key Properties

• CAS Number: 148471-91-4
• MW: 612.72
• Formula: C₃₅H₄₀N₄O₆
• SMILES: COC(C)c1c(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5C(C)O)c(C)c4CCC(O)=O)c(CCC(O)=O)c3C.COC(C)c1c(C)c2cc3nc(cc4[nH]c(cc5nc(cc1[nH]2)c(C)c5CCC(O)=O)c(CCC(O)=O)c4C)c(C)c3C(C)O
• Target: Photosensitizer,Apoptosis
• Solubility: DMSO:50 mg/mL (81.6 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.26 mM)

Bioactivity

• In Vitro:
  Hematoporphyrin monomethyl ether (HMME) is a promising photosensitizer for photodynamic therapy that induces cell death in HeLa cells through both necrosis and apoptosis, primarily via the generation of reactive oxygen species (ROS) like singlet oxygen and hydroxyl radicals.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Hematoporphyrin monomethyl ether, Apoptosis

Compound Identifiers

PubChem CID

176418357