HDAC6-IN-9

SKU: orb1689177

Description

HDAC6-IN-9 is an orally bioavailable γ-secretase modulator. It potently lowers Aβ42 levels in the mouse brain, making it a valuable research tool for investigating Alzheimer's disease and related neurological disorders in both in vivo and in vitro experimental models.

Research Area

Epigenetics & Chromatin, Molecular Biology, Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2796282-58-9
• MW: 320.34
• Purity: 98.84% (May vary between batches)
• Formula: C₁₉H₁₆N₂O₃
• SMILES: O=C(NO)C1=CC=C(C=C1)CC(=O)NC=2C=CC=3C=CC=CC3C2
• Target: Gamma-secretase,HDAC

Bioactivity

• Target IC50:
  HDAC6:4.2 nM|HDAC8:139.6 nM|HDAC3:15.2 nM|HDAC10:21.3 nM|HDAC1:11.8 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

γ-secretase, Gammasecretase

Compound Identifiers

PubChem CID

164517054