HDAC-IN-52

SKU: orb1741381

Description

HDAC-IN-52

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2075787-77-6
• MW: 396.44
• Purity: 98.50% (May vary between batches)
• Formula: C₂₄H₂₀N₄O₂
• SMILES: C(C(NC=1C=CC(C(NC2=C(N)C=CC=C2)=O)=NC1)=O)C3=CC4=C(C=C3)C=CC=C4
• Target: HDAC
• Solubility: DMSO:25 mg/mL (63.06 mM)

Bioactivity

• Target IC50:
  HDAC2:0.227 μM|HDAC3:0.440 μM|HDAC1:0.189 μM|HDAC10:0.446 μM
• In Vitro:
  HDAC-IN-52 (72 h) inhibited the proliferation of HCT116, A549 and K562 cells with IC50 values of 0.43, 1.28 and 0.37 μM, respectively.[1 ]. HDAC-IN-52 (1-5 μM ; 24-48 h) significantly induced cell death in leukemic U937 cells after 48 h, with 76% and 100% G1 prophase blockade, respectively.[1 ] HDAC-IN-52 (1-5 μM ; 48 h) increased mRNA expression of p21, BAX and BAK and downregulated cyclin D1 and BCL-2.[1 ]
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HDAC2, HDAC10, HDAC1, HDAC3

Compound Identifiers

PubChem CID

126571471