HDAC-IN-27 dihydrochloride

SKU: orb3028503

Description

HDAC-IN-27 dihydrochloride (Compound 11h) is a potent, orally active, HDACI class-selective inhibitor, with IC50 values ranging from 0.43 to 3.01 nM for HDAC1-3. This compound exhibits both in vivo and in vitro anticancer activity. HDAC-IN-27 shows significant antiproliferative effects against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). It is useful for research on acute myeloid leukemia (AML).

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 3069831-25-7
• MW: 423.336
• Formula: C₂₀H₂₄Cl₂N₄O₂
• SMILES: O=C(C1=CC=C(CNC(C2=CC3=C(N2)C=CC=C3)=O)C=C1)NNCCC.Cl.Cl
• Target: Apoptosis,HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,HDAC