HBX 41108

SKU: orb1306311

Description

HBX 41108 is a reversible, non-competitive USP7 inhibitor with an IC₅₀ of 424 nM, which effectively blocks USP7-mediated p53 deubiquitination (IC₅₀ = 0.8 µM). This compound is a valuable research tool for studying the p53 pathway and USP7 biology in cancer and neurodegenerative disease models, both in vitro and in vivo.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 924296-39-9
• MW: 266.64
• Purity: 99.65% (May vary between batches)
• Formula: C₁₃H₃ClN₄O
• SMILES: Clc1ccc-2c(c1)C(=O)c1nc(C#N)c(nc-21)C#N
• Target: MDM-2/p53,p53,DUB,Apoptosis
• Solubility: DMSO:60 mg/mL (225.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.75 mM)

Bioactivity

• Target IC50:
  p53:0.8μM|USP7:424nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Deubiquitinase, DUBs, Inhibitor, HBX 41108, HBX41108, HBX-41108, p53, inhibit, USP7

Compound Identifiers

PubChem CID

16065773