HBX 19818

SKU: orb1308233

Description

HBX 19818

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 1426944-49-1
• MW: 421.96
• Purity: 98.76%
• Formula: C₂₅H₂₈ClN₃O
• SMILES: CN(CCCNC(=O)c1ccc2nc3CCCCc3c(Cl)c2c1)Cc1ccccc1
• Target: DUB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.74 mM);DMSO:20 mg/mL (47.4 mM)

Bioactivity

• Target IC50:
  USP7:28.1 μM
• In Vitro:
  HBX 19818 inhibits HCT116 proliferation in a dose-dependent manner (IC50: ～2 μM). HBX 19818 selectively inhibits USP7 (IC50: ～6 μM in human cancer cells). HBX 19818 (1.5, 4, 12, 36, or 100 μM) inhibits USP7 deubiquitination of polyubiquitinated p53. HBX 19818 displays no effects on USP8, USP5, USP10, CYLD, UCH-L1, UCH-L3, or on SENP1, a SUMO protease (IC50s of > 200 μM). HBX 19818 (30 μM) also causes significantly higher levels of Mdm2 polyubiquitinated forms in USP7-overproducing HEK293 cells than those in DMSO-treated control cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Deubiquitinase, DUBs, inhibit, Inhibitor, HBX 19818, HBX19818, HBX-19818, USP7

Compound Identifiers

PubChem CID

73349008