HaloPROTAC-E

SKU: orb2279767

Description

HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14) and no other proteins were significantly degraded.

Key Properties

• CAS Number: 2365478-58-4
• MW: 790.408648490906
• Purity: >98%
• Formula: C₃₉H₅₆CLN₅O₈S
• SMILES: C(C1(CC1)C#N)(=O)N[C@@H](C(C)(C)C)C(N1C[C@H](O)C[C@H]1C(=O)NCC1C=CC(C2SC=NC=2C)=CC=1OCCOCCOCCOCCCCCCCl)=O

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

154723985