H3B-8800

SKU: orb2655822

Description

H3B-8800 is an orally available splicing modulator that targets spliceosome SF3b complex containing either WT or mutant SF3B1 (binding IC50 of 0.3-2 nM); demonstrates dose-dependent inhibition of both canonical splicing and aberrant splicing induced by mutant SF3B1 in in vitro assays of biochemical splicing, induces lethality in spliceosome-mutant cancer cells.Blood Cancer Phase 1 Clinical.

Key Properties

• CAS Number: 1825302-42-8
• MW: 555.716
• Purity: >98% (HPLC)
• Formula: C₃₁H₄₅N₃O₆
• SMILES: O=C(N1CCN(C)CC1)O[C@H]([C@](C)(O)CC[C@@H](O)C2)/C=C/[C@H](C)[C@@H](/C(C)=C/C=C/[C@H](C3=NC=CC=C3)C)OC2=O
• Target: Spliceosome

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

H3B8800

Quick Database Links

Gene Symbol

Spliceosome