H2L 5765834

SKU: orb1218040

Description

H2L 5765834 is a lysophosphatidic acid receptors antagonist.

Key Properties

• CAS Number: 420841-84-5
• MW: 404.33
• Purity: >98% (HPLC)
• Formula: C₂₁H₁₂N₂O₇
• SMILES: [O-][N+](c(cc1)ccc1Oc1cc(N(C(c(cc2)c3cc2C(O)=O)=O)C3=O)ccc1)=O
• Target: LPA Receptor
• Solubility: DMSO:40mg/ml(98.93mM; need ultrasonic)

Bioactivity

• In Vivo:
  H2L 5765834 (20 mg/kg; i.p.) could not affect the LPA-induced decrease of alanine transaminase (ALT) in the acetaminophen (APAP) overdose-induced acute liver injury model.
• In Vitro:
  H2 L 5765834 displays no effect on LPA2 or LPA4 receptors. H2 L 5765834 inhibits LPA-induced platelet shape change with an IC50 of 13.73±2.52 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

LPA Receptor