GW559090

SKU: orb3174957

Description

GW559090 is a selective, competitive, and high-affinity α4 integrin antagonist with a Kd value of 0.19 nM for α4β1. It effectively inhibits the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin, with IC50 values of 7.72 and 8.04 nM, respectively. Additionally, GW559090 suppresses the interaction between α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) with an IC50 value of 23 nM. It also inhibits inflammatory infiltration in the eye, repairs the corneal barrier, and restores goblet cell function, making it useful for research into dry eye syndrome associated with Sjögren's syndrome.

Key Properties

• CAS Number: 278598-52-0
• MW: 596.68
• Formula: C₃₁H₄₀N₄O₈
• SMILES: C([C@H](NC([C@@H](NC(COC1=C(C)C=CC=C1)=O)CC(C)C)=O)C(O)=O)C2=CC=C(OC(=O)N3CCC(C(N)=O)CC3)C=C2
• Target: Integrin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Integrin