GW-6604

SKU: orb1685187

Description

GW-6604

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 452342-37-9
• MW: 298.34
• Purity: 99.26% (May vary between batches)
• Formula: C₁₉H₁₄N₄
• SMILES: c1[nH]nc(c1-c1ccnc(c1)-c1ccccc1)-c1ccccn1
• Target: PAI-1,ALK,TGF-beta/Smad
• Solubility: DMSO:2.99 mg/mL (10.02 mM)

Bioactivity

• In Vivo:
  GW-6604 (40 mg/kg p.o.) increased liver regeneration in TGF-beta-overexpressing mice, which had undergone partial hepatectomy. In an acute model of liver disease, GW-6604 reduced by 80% the expression of collagen IA1. In a chronic model of DMN-induced fibrosis where DMN was administered for 6 weeks and GW-6604 dosed for the last 3 weeks (80 mg/kg p.o., b.i.d.), mortality was prevented and DMN-induced elevations of mRNA encoding for collagen IA1, IA2, III, TIMP-1 and TGF-beta were reduced by 50-75%. Inhibition of matrix genes overexpression was accompanied by reduced matrix deposition and reduction in liver function deterioration, as assessed by bilirubin and liver enzyme levels.
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• In Vitro:
  GW-6604 inhibited autophosphorylation of ALK5 with an IC50 of 140 nM and in a cellular assay inhibited TGF-beta-induced transcription of PAI-1 (IC50 = 500 nM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ALK5, PAI-1, PAI1, GW6604, GW-6604, GW 6604, TGFbeta/Smad, TGF-beta, TGFbeta, TGFb, TGF-b/Smad, TGF-β/Smad, TGFβ, Smad

Compound Identifiers

PubChem CID

9861063