GSK3787

SKU: orb1307037

Description

GSK3787 is a potent, selective, and irreversible antagonist of PPARδ (pIC₅₀ = 6.6). This tool compound is widely used in metabolic and inflammatory disease research, facilitating the study of PPARδ signaling in both cellular assays and animal models.

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 188591-46-0
• MW: 392.78
• Purity: 99.56%
• Formula: C₁₅H₁₂ClF₃N₂O₃S
• SMILES: FC(F)(F)c1ccc(nc1)S(=O)(=O)CCNC(=O)c1ccc(Cl)cc1
• Target: PPAR
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (5.09 mM);DMSO:125 mg/mL (318.24 mM)

Bioactivity

• Target IC50:
  PPARδ:6.6(pIC50)
• In Vivo:
  Pparβ/δ-null mice are administered GSK3787 (10 mg/kg) by oral gavage 3 hours before euthanasia.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, GSK3787, GSK-3787, GSK 3787, PPAR, Peroxisome proliferator-activated receptors, PPARδ

Compound Identifiers

PubChem CID

2800647