GS-680

SKU: orb3032881

Description

GS-680 (GS680) is a novel selective and ATP-competitive CaMKII inhibitor with biochemical IC50 of 2.3 and 15.9 nM against CaMKIIδ and CaMKIIα, respectively.GS-680 inhibited phospholamban phosphorylation in NRVM with an EC50 of 98.9 nM.GS-680 inhibits premature atrial contractions.GS-680 significantly reduced CaMKII autophosphorylation.GS-680 inhibits pro-arrhythmic activity in human atrium and improves contractility in failing human ventricle.

Key Properties

• CAS Number: 3057733-01-1
• MW: 390.465
• Purity: 0.98
• Formula: C₂₀H₁₈N₆OS

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only