GRK5-IN-5

SKU: orb3174378

Description

GRK5-IN-5 (Compound 4a) is a selective inhibitor of G protein-coupled receptor kinase 5 (GRK5) with an IC50 value of 0.03 μM. It shows an IC50 of 2.2 μM for GRK2 and 0.036 μM for GRK6. GRK5-IN-5 exhibits potent anti-hypertrophic activity in cardiac muscle and inhibits the proliferation of non-cardiac cells. It blocks pathological cardiac remodeling by inhibiting the abnormal upregulation of hypertrophic marker genes Nppa and Nppb. GRK5-IN-5 is useful for research in myocardial hypertrophy.

Key Properties

• CAS Number: 3061801-11-1
• MW: 542.57
• Formula: C₃₀H₂₇FN₄O₅
• SMILES: C(=C\1/C=2C(NC1=O)=CC=C(C(N[C@H](C)C3=CC=C(F)C=C3)=O)C2)\C4=C(C)C(NC([C@@H](O)C5=CC=CO5)=O)=C(C)N4
• Target: GRK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GRK