Gracillin

SKU: orb1222573

Description

Gracillin is a steroidal saponin that has been found in C. speciosus and has diverse biological activities. Gracillin induces apoptosis in HL60 human leukemic cell line via oxidative stress and cell cycle arrest of G1.

Key Properties

• CAS Number: 19083-00-2
• MW: 885.05
• Purity: >98% (HPLC)
• Formula: C₄₅H₇₂O₁₇
• SMILES: [C@@H]1([C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O[C@H]1[C@@H]([C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@@H]5O[C@@]6([C@H]([C@@H]5[C@]4(CC[C@@H]3[C@]2(CC1)C)C)C)CC[C@H](CO6)C)CO)O
• Target: cell cycle arrest
• Solubility: In Vitro: DMSO : 100 mg/mL (112.99 mM)

Bioactivity

• In Vitro:
  Apoptosis Analysis Cell line: A549 cells. Concentration: 0-4 μM. Incubation time: 24 h. Result: Induced morphological changes. Apoptosis rate: 6.56%-67.43%.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Gracillin | NSC-698787 | NSC 698787 | NSC698787

Quick Database Links

Gene Symbol

cell cycle arrest