GNE-5152

SKU: orb3136721

Description

GNE-5152 is a straight-chain SARM1 base exchange (BE) inhibitor. Under mild activation conditions, GNE-5152 persistently activates SARM1 at sub-inhibitory concentrations, which synergistically enhances NAD consumption, leading to axonal degeneration and neurodegeneration, and releases neurofilament light chain (NfL) in cortical neurons. GNE-5152 is applicable in neurodegenerative disease research.

Key Properties

• CAS Number: 3080315-83-6
• MW: 365.38
• Formula: C₂₁H₁₇F₂N₃O
• SMILES: O=C1N(C=2C=NC(=CC2)C=3C=CN=CC3)CCC(C4=CC=C(F)C(F)=C4)C1
• Target: TLR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TLR