GNE-0439

SKU: orb1709573

Description

GNE-0439 is a novel, state-dependent Nav1.7 inhibitor (IC50=0.34 µM) with significant selectivity over Nav1.5. Its unique carboxylic acid moiety binds outside the pore, differentiating it from VSD4-targeting compounds. This tool compound is valuable for in vitro electrophysiology and pain research to study sodium channel pharmacology and gating mechanisms.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1241902-40-8
• MW: 345.48
• Purity: 99.60% (May vary between batches)
• Formula: C₂₁H₃₁NO₃
• SMILES: C(N[C@@H]([C@@H](C)C)C(O)=O)(=O)C1=CC=C(C=C1)C2CCC(CCC)CC2
• Target: Sodium Channel
• Solubility: DMSO:105 mg/mL (303.92 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:4 mg/mL (11.58 mM)

Bioactivity

• Target IC50:
  Nav1.7:0.34 uM

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nav1.7, GNE0439, GNE-0439, GNE 0439

Compound Identifiers

PubChem CID

92138726