Glyburide-d3

SKU: orb3138422

Description

Glyburide-d3 is the deuterated form of Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor, utilized in the research of diabetes and obesity. It inhibits P-glycoprotein, directly binds to and blocks the SUR1 subunit of KATP, and suppresses the cystic fibrosis transmembrane conductance regulator (CFTR). Additionally, Glibenclamide interferes with mitochondrial bioenergetics by inducing membrane ion permeability and can induce autophagy.

Key Properties

• CAS Number: 1219803-02-7
• MW: 497.02
• Formula: C₂₃H₂₈ClN₃O₅S
• SMILES: C(NCCC1=CC=C(S(NC(NC2CCCCC2)=O)(=O)=O)C=C1)(=O)C3=C(OC([2H])([2H])[2H])C=CC(Cl)=C3
• Target: P-gp,Mitochondrial Metabolism,CFTR,Autophagy,Potassium Channel

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

P-gp,Mitochondrial Metabolism,CFTR,Autophagy,Potassium Channel