Glyburide-d11

SKU: orb3138867

Description

Glyburide-d11 is a deuterated form of Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor used in the study of diabetes and obesity. It inhibits P-glycoprotein and directly binds to block the SUR1 subunit of KATP, also inhibiting cystic fibrosis transmembrane conductance regulator (CFTR). Glibenclamide interferes with mitochondrial bioenergetics by inducing membrane ion permeability and can induce autophagy.

Key Properties

• CAS Number: 1189985-02-1
• MW: 505.07
• Formula: C₂₃H₂₈ClN₃O₅S
• SMILES: C(NCCC1=CC=C(S(NC(NC2(C(C(C(C(C2([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])[2H])=O)(=O)=O)C=C1)(=O)C3=C(OC)C=CC(Cl)=C3
• Target: Mitochondrial Metabolism,CFTR,Potassium Channel,P-gp,Autophagy

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Mitochondrial Metabolism,CFTR,Potassium Channel,P-gp,Autophagy