Gly-Gly-Gly-PEG4-DBCO

SKU: orb1988333

Description

This product is a cleavable linker for constructing antibody-drug conjugates (ADCs), featuring a Gly-Gly-Gly tripeptide and a tetraethylene glycol (PEG4) spacer terminated with a DBCO group. It enables site-specific conjugation via strain-promoted azide-alkyne cycloaddition (SPAAC) and is suitable for developing ADCs for both in vitro and in vivo cancer research applications.

Key Properties

• CAS Number: 2353409-80-8
• MW: 694.77
• Formula: C₃₅H₄₆N₆O₉
• SMILES: O=C(NCC(=O)NCC(=O)NCCOCCOCCOCCOCCNC(=O)CCC(=O)N1C=2C=CC=CC2C#CC=3C=CC=CC3C1)CN
• Target: ADC Linker
• Solubility: Methanol:50 mg/mL (71.97 mM);DMSO:80 mg/mL (115.15 mM)

Bioactivity

• In Vitro:
  ADCs consist of an antibody conjugated to an ADC cytotoxin via an ADC linker.

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADC Linker, ADC linker, ADCLinker, Cleavable, Gly Gly Gly PEG4 DBCO, GlyGlyGlyPEG4DBCO, Gly-Gly-Gly-PEG-4-DBCO, Gly-Gly-Gly-PEG4-DBCO

Compound Identifiers

PubChem CID

137334056