Glucosamine

SKU: orb1225251

Description

Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies. It is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis. (In Vitro):Glucosamine (D-Glucosamine) exhibits dose-dependent DPPH antioxidant activity.Glucosamine treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins.Glucosamine significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells.

Key Properties

• CAS Number: 3416-24-8
• MW: 179.17
• Purity: >98% (HPLC)
• Formula: C₆H₁₃NO₅
• SMILES: NC(C=O)C(O)C(O)C(O)CO
• Target: CFTR
• Solubility: Water: 551.0 mg/mL

Bioactivity

• In Vitro:
  Glucosamine (D-Glucosamine) exhibits dose-dependent DPPH antioxidant activity. Glucosamine treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins. Glucosamine significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CFTR