GLPG2451

SKU: orb1707950

Description

GLPG2451 is a potent CFTR enhancer with an EC50 of 11.1 nM for cold-rescued F508del-CFTR. It is a valuable research tool for investigating CFTR function and potential therapeutic strategies for cystic fibrosis in both cellular and animal model systems.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2055015-61-5
• MW: 419.38
• Purity: 99.13%
• Formula: C₁₆H₁₆F₃N₃O₅S
• SMILES: S(=O)(=O)(C=1C=C(N)C(C(NC[C@H](C)O)=O)=NC1)C2=CC=C(OC(F)(F)F)C=C2
• Target: CFTR
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (7.87 mM);DMSO:200 mg/mL (476.89 mM)

Bioactivity

• In Vitro:
  The EC50 value of GLPG2451 in G551D/F508del-type cells is 675 nM, with its pharmacological activity reaching 147% of VX770 .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GLPG 2451, GLPG2451, GLPG-2451, Cystic fibrosis transmembrane conductance regulator, CysteineProtease, Cysteine Protease

Compound Identifiers

PubChem CID

124106089