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GK444

SKU: orb1942452

Description

GK444 (Compound 15a) is a selective HDAC1/2 inhibitor with IC50 values of 100 nM for HDAC1 and 92 nM for HDAC2. It exhibits an IC50 of 4.1 μM in Caco-2 cells, attenuates TGF-β1-induced COL1A1 mRNA in human lung fibroblasts, and mitigates Bleomycin-induced lung fibrosis in mice, applicable in fibrosis and epigenetic research.

Research Area

Epigenetics & Chromatin, Molecular Biology

Images & Validation

Key Properties

TargetHDAC

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information