Giripladib

SKU: orb1697103

Description

Giripladib (PLA695, PLX-695) is a selective cPLA2 inhibitor that suppresses radiation-induced phosphorylation of ERK and Akt in endothelial cells. This small molecule is utilized in cardiovascular and radiation biology research, with applications in both in vitro cellular studies and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 865200-20-0
• MW: 745.25
• Purity: 99.68%
• Formula: C₄₁H₃₆ClF₃N₂O₄S
• SMILES: C(N1C(CCNS(CC2=C(C(F)(F)F)C=CC=C2)(=O)=O)=C(CCCC3=CC=C(C(O)=O)C=C3)C=4C1=CC=C(Cl)C4)(C5=CC=CC=C5)C6=CC=CC=C6
• Target: Phospholipase
• Solubility: DMSO:7.46 mg/mL (10.01 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PLA695, PLA-695, PLA 695, cPLA2, Giripladib

Compound Identifiers

PubChem CID

11721842