Gimatecan HCl

SKU: orb1819286

Description

Gimatecan HCl (ST1481 HCl) is an orally active camptothecin analog that acts as a potent topoisomerase I inhibitor. It demonstrates antitumor activity in both in vitro cytotoxicity assays and in vivo xenograft models, supporting its investigation in oncology research.

Research Area

Molecular Biology

Key Properties

• MW: 483.94
• Purity: 97.04% (May vary between batches)
• Formula: C₂₅H₂₆ClN₃O₅
• SMILES: CC(C)(C)O/N=C/C1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC=CC=C51.Cl
• Target: Topoisomerase
• Solubility: DMSO:4.84 mg/mL (10 mM)

Bioactivity

• In Vivo:
  Gimatecan HCl (2 mg/kg; treatment per os, every fourth day for four times) is effective for inhibiting tumor growth .
• In Vitro:
  Gimatecan HCl (3 to 300 ng/mL) significantly inhibits the growth of human bladder cancer models (HT1376 and MCR), thus reflecting antiproliferative potency. Gimatecan HCl causes a persistent S-phase arrest At 0.003 µg/mL and the number of S-phase cells increased after treatment with a higher concentration (0.03 µg/mL).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Gimatecan HCl(292618-32-7 Free base), Gimatecan HCl, ST1481 HCL, topoisomerase I

Compound Identifiers

PubChem CID

169553380