Gepotidacin mesylate dihydrate

SKU: orb1739122

Description

Gepotidacin mesylate dihydrate (GSK2140944) is an oral triazaacenaphthylene antibiotic that inhibits bacterial type II topoisomerase, thereby blocking DNA replication. It is used in research for studying bacterial infections, with applications in both in vitro antibacterial assays and in vivo infection models.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 1624306-20-2
• MW: 580.65
• Purity: 99.85% (May vary between batches)
• Formula: C₂₅H₃₆N₆O₈S
• SMILES: CS(=O)(O)=O.O=C1N(C2)C(N3[C@@H]2CN4CCC(CC4)NCC5=NC=C(OCCC6)C6=C5)=C(N=CC3=O)C=C1.O.O
• Target: Topoisomerase,Antibacterial,Antibiotic,Autophagy

Bioactivity

• Target IC50:
  E. coli:1~4 mg/L (MIC)|positive superhelix substrate relaxation:0.6 μM|catalase-catalyzed DNA superhelix:0.047 μM
• In Vitro:
  Gepotidacin mesylate dihydrate is a potent inhibitor for catalase-catalyzed DNA superhelix (IC50 ≈ 0.047 μM) and inhibit positive superhelix substrate relaxation (IC50 ≈ 0.6 μM). Gepotidacin mesylate dihydrate against E. coli isolates from Mueller-Hinton. The MIC ranged from 1 to 4 mg/L.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antibacterial, Autophagy, GSK2140944 mesylate dihydrate, GSK-2140944 mesylate dihydrate, GSK 2140944 mesylate dihydrate, Gepotidacin Mesylate, Gepotidacin mesylate Dihydrate, GK-128 hydrochloride, GK-128 monohydrochloride

Compound Identifiers

PubChem CID

91668189