Gentamicin sulfate

SKU: orb1308972

Description

Gentamicin sulfate is an orally active, broad-spectrum aminoglycoside antibiotic. It inhibits bacterial protein synthesis and is widely used in both in vitro microbiological studies and in vivo models of bacterial infection for research purposes.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1405-41-0
• MW: 1488.79
• Purity: ≥98% (May vary between batches)
• Formula: C₆₀H₁₂₅N₁₅O₂₅S
• SMILES: CC([C@@H]1CC[C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@](CO3)(C)O)NC)O)N)N)N)N.CC([C@@H]1CC[C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@](CO3)(C)O)NC)O)N)N)N)NC.C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@@H]3[C@@H](CC[C@H](O3)CN)N)N)N)O.OS(=O)(=O)O
• Target: DHFR,ribosome,Antibacterial,Antibiotic
• Solubility: H2O:255 mg/mL;DMSO:Insoluble

Bioactivity

• Target IC50:
  MDCK cells:32 mM|DNase I:0.57 mM|Streptococcus faecalis:< 40 μg/mL
• In Vivo:
  Gentamicin is the first choice aminoglycoside for the treatment of serious infections at present, with alternatives being amikacin, netilmicin, and tobramycin. Gentamicin preparations are commercially available in three forms, namely otic, ophthalmic, and topical based on the respective function to treat infections of ear canal, eye, and skin. Oral and injectable forms of gentamicin are found to exhibit effective antibacterial activity against Yersinia pestis as demonstrated in a mouse infection model. Treatment with up to nine doses of methicillin or gentamicin shows an obvious reduction of bacteria on the foreign body.
• In Vitro:
  METHODS: Fibroblasts, MDCK and LLC-PK1 cells were treated with Gentamicin sulfate (0-3 mM) for 4 days and apoptosis was detected by TUNEL assay. RESULTS: The incidence of apoptosis was increased in all 3 cell lines, correlating almost directly with the extracellular concentration of Gentamicin sulfate and the incubation time, reaching 20-30% of all cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DHFR, DNase I, 30S ribosome, 16S ribosome, Bacterial, Antibiotic, glandular tularemia, Meniere's disease, Gentamicin sulfate, Gentamicin Sulfate, Gentamicin, Gentamycin Sulfate, Gentamycin sulfate, orally active, NSC82261, NSC-82261, inhibit, NSC 82261, Inhibitor, SCH 9724, SCH9724, SCH-9724

Compound Identifiers

PubChem CID

6419933