GED-0507-34 Levo

SKU: orb2814927

Description

GED-0507-34 Levo is an orally active PPARγ modulator that attenuates intestinal fibrosis by suppressing key pro-fibrotic pathways. It downregulates expression of Acta2, COL1a1, Fn1, α-SMA, collagen, and TGFβ/Smad components, and inhibits TGF-β-driven activation in both fibroblast and intestinal epithelial cell lines in vitro.

Research Area

Immunology & Inflammation, Metabolism Research, Molecular Biology, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 921195-93-9
• MW: 195.22
• Purity: 98.19%
• Formula: C₁₀H₁₃NO₃
• SMILES: C([C@@H](C(O)=O)OC)C1=CC=C(N)C=C1
• Target: PPAR,Interleukin,TGF-beta/Smad

Bioactivity

• In Vivo:
  C57BL/6 mice (n = 110) were administered 2.5% DSS in drinking water (3 cycles over 6 weeks) to induce intestinal fibrosis, and treated daily with GED-0507-34 Levo (30 mg/kg/d; oral). Fibrosis severity was evaluated via macroscopic/histological scores and fibrosis marker expression. GED-0507-34 Levo treatment alleviated intestinal fibrosis.
• In Vitro:
  GED-0507-34 Levo was added to TGF-β–stimulated intestinal fibroblasts, epithelial cell lines, and primary fibroblasts from ulcerative colitis patients. Expression of α-SMA, Fn1, TGF-β, ACTA1, and epithelial markers was assessed. GED-0507-34 Levo inhibited TGF-β–induced fibrotic activation.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(S)-3-(4-Aminophenyl)-2-methoxypropanoic acid, (S)-3-(4-Aminophenyl)-2-methoxypropanoicacid, Y4H78S56YZ

Compound Identifiers

PubChem CID

67008033